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Antimicrobial Agents and Chemotherapy, August 1999, p. 2056-2058, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Penetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients

Markus Müller,1,* Martin Brunner,1 Ursula Hollenstein,2 Christian Joukhadar,1 Rainer Schmid,3 Erich Minar,4 Herbert Ehringer,4 and Hans Georg Eichler1

Departments of Clinical Pharmacology,1 Internal Medicine I, Division of Infectious Diseases and Chemotherapy,2 Medical and Chemical Laboratory Diagnosis,3 and Internal Medicine II, Division of Angiology,4 University of Vienna Medical School, Vienna, Austria

Received 20 November 1998/Returned for modification 17 April 1999/Accepted 25 May 1999

Interstitial ciprofloxacin concentrations were measured by microdialysis in inflamed foot lesions of non-insulin-dependent diabetes mellitus patients following intravenous administration of 0.2 g of ciprofloxacin. Interstitial ciprofloxacin concentrations were significantly lower than corresponding serum concentrations. There was no significant difference in the penetration of ciprofloxacin into inflamed and unaffected tissue (area under the concentration-time curveinfection/area under the concentration-time curveunaffected tissue = 0.99 ± 0.15 [mean ± standard error], n = 6). Thus, inflammation appears to have little or no effect on the penetration of ciprofloxacin into tissue.

* Corresponding author. Mailing address: Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, University of Vienna Medical School, Allgemeines Krankenhaus, Währinger Gürtel 18-20, A-1090 Vienna, Austria. Phone: 43-1-40400-2981. Fax: 43-1-40400-2998. E-mail: markus.mueller{at}univie.ac.at.

Antimicrobial Agents and Chemotherapy, August 1999, p. 2056-2058, Vol. 43, No. 8
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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