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Antimicrobial Agents and Chemotherapy, March 2002, p. 859-862, Vol. 46, No. 3
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.3.859-862.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Optimal Dose of Amoxicillin in Treatment of Otitis Media Caused by a Penicillin-Resistant Pneumococcus Strain in the Gerbil Model

Departments of Medical Microbiology,¹ Otolaryngology, Fundación Jiménez Díaz,² Medical Department, GlaxoSmithKline, Madrid, Spain³

Received 16 April 2001/ Returned for modification 20 September 2001/ Accepted 16 November 2001

Amoxicillin at doses of 0.2 to 5 mg/kg of body weight was administered for the treatment of pneumococcal otitis media in a gerbil model. Doses greater than or equal to 2.5 mg/kg, which resulted in concentrations in middle ear fluid of 1.4 µg/ml and concentrations in serum higher than the MIC (1 µg/ml) for 14% of the dosing interval, were both clinically and bacteriologically effective.

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