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Antimicrobial Agents and Chemotherapy, April 2002, p. 1098-1100, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1098-1100.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

First Description of Klebsiella pneumoniae Harboring CTX-M ß-Lactamases (CTX-M-14 and CTX-M-3) in Taiwan

University of Iowa College of Medicine,¹ The Veterans Affairs Medical Center, Iowa City,³ The JONES Group/JMI Laboratories, North Liberty, Iowa,⁴ China Medical College Hospital, Taichung City, Taiwan²

Received 18 July 2001/ Returned for modification 12 November 2001/ Accepted 18 January 2002

Klebsiella pneumoniae isolates from Taiwan medical centers (50 strains; 1998 to 2000) with a CTX-M resistance phenotype (ceftazidime susceptible and ceftriaxone or cefotaxime nonsusceptible) were selected for initial isoelectric focusing analysis. ß-Lactamases with pIs of 7.9 (n = 22) and 8.4 (n = 28) in addition to 5.4 and/or 7.6 were detected. DNA gene sequencing identified the ß-lactamases with pIs of 7.9 and 8.4 as CTX-M-14 and CTX-M-3, respectively. Molecular typing suggested inter- and intrahospital clonal dissemination of these Taiwanese CTX-M-producing Klebsiella strains.

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