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Antimicrobial Agents and Chemotherapy, April 2002, p. 1112-1113, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1112-1113.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Potent In Vitro Antimalarial Activity of Metacycloprodigiosin Isolated from Streptomyces spectabilis BCC 4785

Masahiko Isaka,* Amonlaya Jaturapat, Jarin Kramyu, Morakot Tanticharoen, and Yodhathai Thebtaranonth

National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Bangkok 10400, Thailand

Received 17 August 2001/ Returned for modification 4 December 2001/ Accepted 2 January 2002

Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A1, and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1, with a 50% inhibitory concentration of 0.0050 ± 0.0010 µg/ml, while its cytotoxicity was much weaker.

* Corresponding author. Mailing address: National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Rama 6 Rd., Bangkok 10400, Thailand. Phone: (662) 6448103. Fax: (662) 6448107. E-mail: isaka{at}biotec.or.th.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1112-1113, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1112-1113.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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Copyright © 2002 by the American Society for Microbiology. All rights reserved.