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Antimicrobial Agents and Chemotherapy, April 2002, p. 1153-1155, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1153-1155.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Lack of Catheter Infection by the efg1/efg1 cph1/cph1 Double-Null Mutant, a Candida albicans Strain That Is Defective in Filamentous Growth

Russell E. Lewis,1,2 Hsiu-Jung Lo,3 Issam I. Raad,1 and Dimitrios P. Kontoyiannis1*

Department of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030,1 University of Houston College of Pharmacy, Houston, Texas 77204,2 National Health Research Institutes, Taipei, Taiwan, Republic of China3

Received 7 November 2001/ Returned for modification 10 December 2001/ Accepted 2 January 2002

The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.

* Corresponding author. Mailing address: Department of Infectious Diseases, Box 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. Phone: (713) 792-6237. Fax: (713) 745-6839. E-mail: dkontoyi{at}mdanderson.org.

Antimicrobial Agents and Chemotherapy, April 2002, p. 1153-1155, Vol. 46, No. 4
0066-4804/02/$04.00+0     DOI: 10.1128/AAC.46.4.1153-1155.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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