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Antimicrobial Agents and Chemotherapy, December 2008, p. 4507-4509, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00915-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus{triangledown}

Daniel R. Gentry,* Lynn McCloskey, Michael N. Gwynn, Stephen F. Rittenhouse, Nicole Scangarella, Ribhi Shawar, and David J. Holmes

Department of Microbiology, ID-CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426

Received 10 July 2008/ Returned for modification 1 September 2008/ Accepted 29 September 2008

Retapamulin MICs of ≥2 µg/ml were noted for 6 of 5,676 S. aureus recent clinical isolates evaluated. The ABC proteins VgaAv and VgaA were found to be responsible for the reduced susceptibility to pleuromutilins exhibited by these six isolates.

* Corresponding author. Mailing address: UP1345, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, PA 19426. Phone: (610) 917-7504. Fax: (610) 917-7901. E-mail: dan.r.gentry{at}gsk.com

{triangledown} Published ahead of print on 6 October 2008.

Antimicrobial Agents and Chemotherapy, December 2008, p. 4507-4509, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00915-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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