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Antimicrobial Agents and Chemotherapy, December 2008, p. 4514-4517, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00563-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Characterization of pUO-StVR2, a Virulence-Resistance Plasmid Evolved from the pSLT Virulence Plasmid of Salmonella enterica Serovar Typhimurium{triangledown}

Ana Herrero,1 M. Carmen Mendoza,1 Rosaura Rodicio,2 and M. Rosario Rodicio1*

Departamento de Biología Funcional (Área de Microbiología) and Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain,1 Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33006 Oviedo, Spain2

Received 30 April 2008/ Returned for modification 5 July 2008/ Accepted 4 October 2008

pUO-StVR2 is a virulence-resistance plasmid which originated from pSLT of Salmonella enterica serovar Typhimurium through acquisition of a complex resistance island, flanked by regions that provide a toxin-antitoxin system and an iron uptake system. The presence of resistance and virulence determinants on the same plasmid allows coselection of both properties, potentially increasing health risks.

* Corresponding author. Mailing address: Área de Microbiología, Facultad de Medicina, Universidad de Oviedo, Julián Clavería no. 6, 33006 Oviedo, Spain. Phone: 34 985103562. Fax: 34 985103148. E-mail: rrodicio{at}fq.uniovi.es

{triangledown} Published ahead of print on 13 October 2008.

Antimicrobial Agents and Chemotherapy, December 2008, p. 4514-4517, Vol. 52, No. 12
0066-4804/08/$08.00+0     doi:10.1128/AAC.00563-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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