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Antimicrobial Agents and Chemotherapy, June 2008, p. 2239-2241, Vol. 52, No. 6
0066-4804/08/$08.00+0     doi:10.1128/AAC.00009-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vivo Efficacy of β-Cyclodextrin Derivatives against Anthrax Lethal Toxin

Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,¹ Innovative Biologics, Inc., 13455 Sunrise Valley Dr., Suite 200, Herndon, Virginia 20171²

Received 2 January 2008/ Returned for modification 14 February 2008/ Accepted 17 March 2008

We evaluated the in vivo efficacy of three β-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described β-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection.

Published ahead of print on 31 March 2008.