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Antimicrobial Agents and Chemotherapy, August 2008, p. 2947-2949, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01570-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Identification of Mutations Related to Streptomycin Resistance in Clinical Isolates of Mycobacterium tuberculosis and Possible Involvement of Efflux Mechanism{triangledown} ,{dagger}

Fernanda S. Spies,1,2 Pedro E. Almeida da Silva,3 Marta O. Ribeiro,2 Maria Lucia Rossetti,2,4 and Arnaldo Zaha1,5*

Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil,1 Fundação Estadual de Produção e Pesquisa em Saúde do Estado do Rio Grande do Sul, Porto Alegre, Brazil,2 Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande, Campus da Saúde, Rio Grande, Brazil,3 Programa de Pós-graduação em Ciências em Genética e Toxicologia Aplicada-Universidade Luterana do Brasil, Canoas, Brazil,4 Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil5

Received 6 December 2007/ Returned for modification 17 January 2008/ Accepted 3 June 2008

The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL, rrs, and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act synergistically to confer low STR resistance.

* Corresponding author. Mailing address: Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Rua Bento Gonçalves 9500, Prédio 43421, CEP 91501-970 Porto Alegre, RS, Brazil. Phone: 55 51 33086054. Fax: 55 51 33087309. E-mail: zaha{at}cbiot.ufrgs.br

{triangledown} Published ahead of print on 9 June 2008.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, August 2008, p. 2947-2949, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.01570-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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