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Antimicrobial Agents and Chemotherapy, August 2008, p. 2977-2979, Vol. 52, No. 8
0066-4804/08/$08.00+0     doi:10.1128/AAC.00175-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

VIM-15 and VIM-16, Two New VIM-2-Like Metallo-β-Lactamases in Pseudomonas aeruginosa Isolates from Bulgaria and Germany

MICOER-Institute, Munich, Germany,¹ Medical Institute, Ministry of the Interior, Sofia, Bulgaria,² Medizinisches Versorgungszentrum Labor Dr. Tiller and Partner, Munich, Germany,³ Department of Microbiology, Medical University, Sofia, Bulgaria,⁴ Johnson & Johnson Pharmaceutical Research and Development, Raritan, New Jersey⁵

Received 7 February 2008/ Returned for modification 27 March 2008/ Accepted 28 May 2008

Two Pseudomonas aeruginosa urine isolates from Bulgaria and Germany produced two new VIM-2 variants. VIM-15 had one amino acid substitution (Tyr218Phe) which caused a significant increase in hydrolytic efficiency. The substitution Ser54Leu, characterizing VIM-16, showed no influence on enzyme activity. Both genes were part of class I integrons located in the chromosome.

Published ahead of print on 2 June 2008.