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Antimicrobial Agents and Chemotherapy, September 2008, p. 3408-3410, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00501-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Recombination and Selection Can Remove bla_TEM Alleles from Bacterial Populations

School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, California

Received 16 April 2008/ Returned for modification 5 June 2008/ Accepted 3 July 2008

We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla_TEM-1 allele from the bacterial population when it was passaged through ceftazidime or the bla_TEM-12 allele when cultures were passaged through ampicillin.

Published ahead of print on 14 July 2008.

This article has been cited by other articles:

• Barlow, M., Fatollahi, J., Salverda, M. (2008). Evidence for recombination among the alleles encoding TEM and SHV {beta}-lactamases. J Antimicrob Chemother 0: dkn475v1-4 [Abstract] [Full Text]