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Antimicrobial Agents and Chemotherapy, September 2008, p. 3430-3432, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00591-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Real-Time PCR and Statistical Analyses of acrAB and ramA Expression in Clinical Isolates of Klebsiella pneumoniae{triangledown}

Alexey Ruzin,1* Frederick W. Immermann,2 and Patricia A. Bradford1

Department of Infectious Disease, Wyeth Research, Pearl River, New York 10965,1 Translational Medicine Biostatistics, Wyeth Research, Pearl River, New York 109652

Received 6 May 2008/ Returned for modification 9 June 2008/ Accepted 4 July 2008

Clinical isolates of Klebsiella pneumoniae were tested for a correlation between tigecycline MIC and expression of ramA by using real-time PCR. At MICs of 4 and 8 µg/ml, the expression of ramA was statistically significantly different from MICs of 2 µg/ml or less, supporting the tigecycline susceptibility breakpoint of ≤2 µg/ml for K. pneumoniae.

* Corresponding author. Mailing address: Department of Infectious Disease, Wyeth Research, 401 North Middletown Road, Bldg. 200, Rm. 3218, Pearl River, NY 10965. Phone: (845) 602-4592. Fax: (845) 602-5671. E-mail: ruzina{at}wyeth.com

{triangledown} Published ahead of print on 14 July 2008.

Antimicrobial Agents and Chemotherapy, September 2008, p. 3430-3432, Vol. 52, No. 9
0066-4804/08/$08.00+0     doi:10.1128/AAC.00591-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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