This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Poirel, L.
Right arrow Articles by Nordmann, P.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Poirel, L.
Right arrow Articles by Nordmann, P.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2009, p. 4940-4943, Vol. 53, No. 11
0066-4804/09/$08.00+0     doi:10.1128/AAC.00414-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

ISCR2, Another Vehicle for blaVEB Gene Acquisition{triangledown}

Laurent Poirel,1 Pauline D. Mugnier,1 Mark A. Toleman,2 Timothy R. Walsh,2 Melina J. Rapoport,3 Alejandro Petroni,3 and Patrice Nordmann1*

Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud et Université Paris-Sud, Le Kremlin-Bicêtre, France,1 Department of Medical Microbiology, School of Medicine, Cardiff University, Cardiff, United Kingdom,2 Servicio Antimicrobianos, Departamento Bacteriologia, Instituto Nacional de Enfermedades Infecciosas-ANLIS Dr. Carlos G. Malbran, Buenos Aires, Argentina3

Received 27 March 2009/ Returned for modification 31 May 2009/ Accepted 13 August 2009

The expanded-spectrum β-lactamase (ESBL) gene blaVEB-1, identified worldwide in Enterobacteriaceae and Pseudomonas aeruginosa, is associated with either class 1 integrons or repeated elements. We report here the first association of blaVEB-1a with the insertion sequence ISCR2 in six Acinetobacter species isolates recovered from Argentina. That genetic structure was likely at the origin of the mobilization of this ESBL gene.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 24 August 2009.

Antimicrobial Agents and Chemotherapy, November 2009, p. 4940-4943, Vol. 53, No. 11
0066-4804/09/$08.00+0     doi:10.1128/AAC.00414-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»