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Antimicrob. Agents Chemother. doi:10.1128/AAC.00062-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis

Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil, CEP 21045-900; Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Rural do Rio de Janeiro, RJ, Brasil; Departamento de Imunobiologia, Instituto de Biologia, Universidade Federal Fluminense –Niterói, RJ, Brasil

	Abstract

Efficacy of two mesoionic derivatives (MI-H-H and MI-4-OCH₃) was evaluated in CBA/J mice infected with Leishmania amazonensis. The treatment with these compounds demonstrated that MI-4-OCH₃ derivative and the reference drug Glucantime presented significant activity relative to untreated control. No apparent hepatic or renal toxicity was found for these mesoionic compounds.