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Antimicrob. Agents Chemother. doi:10.1128/AAC.00603-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Ultrastructural Effects of Oritavancin on Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus

Targanta Therapeutics Inc. 7170 Frederick Banting, St. Laurent, Quebec; MicroTEM Inc., P.O. Box 1107, 101 Chalmers St., Elora, Ontario, Canada N0B 1S0

^* To whom correspondence should be addressed. Email: gmoeck{at}targanta.com.

	Abstract

The ultrastructural effects of the lipoglycopeptide oritavancin on methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were examined by transmission electron microscopy. Oritavancin but not vancomycin induced aberrant septum formation and loss of staining of nascent septal cross walls in MRSA. Septal distortions were also observed in VRE exposed to oritavancin.