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AAC Accepts, published online ahead of print on 17 November 2008
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00960-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Comparison of the performance of two in-house rapid methods for anti-tubercular drug susceptibility testing

Agustina I. de la Iglesia, Emma J. Stella, and Héctor R. Morbidoni*

Cátedra de Microbiología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina

* To whom correspondence should be addressed. Email: morbiatny{at}yahoo.com.


  Abstract

Resistance to Rifampicin, Isoniazid and Streptomycin of 69 Mycobacterium tuberculosis isolates was analyzed by an in-house method based on mycobacteriophage D29 and a colorimetric micro-method. Both methods showed sensitivity and specificity values ranging from 93% to 100%. These simple methods offer an option for drug resistance assessment of M. tuberculosis.






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