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Antimicrob. Agents Chemother. doi:10.1128/AAC.00987-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

First Report on Hyper-Epidemic Clone of KPC-3 Producing Klebsiella pneumoniae in Israel Genetically Related to a Strain Causing Outbreaks in the United States

Epidemiology Division, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv., Center of Disease Control and Prevention, Atlanta, Georgia

^* To whom correspondence should be addressed. Email: shiri_nv{at}tasmc.health.gov.il.

	Abstract

A highly epidemic carbapenem-resistant clone of KPC-3-producing Klebsiella pneumoniae emerged in Israel in 2006, causing a nationwide outbreak. This clone was genetically related to US outbreak strains isolated in 2000 but differed in KPC-carrying plasmids. The threat of global spread of hyper-epidemic extensively-drug-resistant bacterial strains should be recognized and confronted.