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Antimicrob. Agents Chemother. doi:10.1128/AAC.01007-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

CTX-M expression and selection of ertapenem resistance in Klebsiella pneumoniae and Escherichia coli

Service de Bactériologie-Virologie, INSERM U914 «Emerging Resistance to Antibiotics», Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Sud, 94275 K. -Bicêtre, France

^* To whom correspondence should be addressed. Email: nordmann.patrice{at}bct.aphp.fr.

	Abstract

In-vitro selection of mutants with decreased susceptibility to ertapenem was performed using Escherichia coli and Klebsiella pneumoniae clinical strains producing either the bla_CTX-M-2, bla_CTX-M-3, bla_CTX-M-9, or bla_CTX-M-15 gene. Frequency of mutants with decreased susceptibility to ertapenem was similar whatever the -lactamase was expressed.