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Minireviews:

Daniel Boden and Martin Markowitz

Resistance to Human Immunodeficiency Virus Type 1 Protease Inhibitors
Antimicrob. Agents Chemother. 1998 42: 2775-2783. [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Ann Hsu, G. Richard Granneman, Guoliang Cao, Lori Carothers, Anthony Japour, Tawakol El-Shourbagy, Suzana Dennis, Jeanne Berg, Keith Erdman, John M. Leonard, and Eugene Sun

Pharmacokinetic Interaction between Ritonavir and Indinavir in Healthy Volunteers
Antimicrob. Agents Chemother. 1998 42: 2784-2791. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Alexander A. Firsov, Sergey N. Vostrov, Alexander A. Shevchenko, Yury A. Portnoy, and Stephen H. Zinner

A New Approach to In Vitro Comparisons of Antibiotics in Dynamic Models: Equivalent Area under the Curve/MIC Breakpoints and Equiefficient Doses of Trovafloxacin and Ciprofloxacin against Bacteria of Similar Susceptibilities
Antimicrob. Agents Chemother. 1998 42: 2841-2847. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Alexander A. Firsov, Sergey N. Vostrov, Alexander A. Shevchenko, Stephen H. Zinner, Giuseppe Cornaglia, and Yury A. Portnoy

MIC-Based Interspecies Prediction of the Antimicrobial Effects of Ciprofloxacin on Bacteria of Different Susceptibilities in an In Vitro Dynamic Model
Antimicrob. Agents Chemother. 1998 42: 2848-2852. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Leta Posho, Laurence Delbos-Bocage, Delphine Gueylard, Robert Farinotti, and Claude Carbon

Effects of Salmonella typhimurium Infection and Ofloxacin Treatment on Glucose and Glutamine Metabolism in Caco-2/TC-7 Cells
Antimicrob. Agents Chemother. 1998 42: 2950-2955. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Caroline Solas, Yu-Feng Li, Meng-Yu Xie, Jean-Pierre Sommadossi, and Xiao-Jian Zhou

Intracellular Nucleotides of ()-2',3'-Deoxy-3'-Thiacytidine in Peripheral Blood Mononuclear Cells of a Patient Infected with Human Immunodeficiency Virus
Antimicrob. Agents Chemother. 1998 42: 2989-2995. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Giorgio Gatti, Marina Malena, Rosetta Casazza, Marie Borin, Matteo Bassetti, and Mario Cruciani

Penetration of Clindamycin and Its Metabolite N-Demethylclindamycin into Cerebrospinal Fluid following Intravenous Infusion of Clindamycin Phosphate in Patients with AIDS
Antimicrob. Agents Chemother. 1998 42: 3014-3017. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

Irene González, Marios Georgiou, Fernando Alcaide, Delia Balas, Josefina Liñares, and Adela G. de la Campa

Fluoroquinolone Resistance Mutations in the parC, parE, and gyrA Genes of Clinical Isolates of Viridans Group Streptococci
Antimicrob. Agents Chemother. 1998 42: 2792-2798. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

M. J. Gill, S. Simjee, K. Al-Hattawi, B. D. Robertson, C. S. F. Easmon, and C. A. Ison

Gonococcal Resistance to -Lactams and Tetracycline Involves Mutation in Loop 3 of the Porin Encoded at the penB Locus
Antimicrob. Agents Chemother. 1998 42: 2799-2803. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Xiao-Su Pan and L. Mark Fisher

DNA Gyrase and Topoisomerase IV Are Dual Targets of Clinafloxacin Action in Streptococcus pneumoniae
Antimicrob. Agents Chemother. 1998 42: 2810-2816. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Xiang Qin, Kavindra V. Singh, Yi Xu, George M. Weinstock, and Barbara E. Murray

Effect of Disruption of a Gene Encoding an Autolysin of Enterococcus faecalis OG1RF
Antimicrob. Agents Chemother. 1998 42: 2883-2888. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anne Casetta, Annie Buu Hoï, Gilda de Cespédès, and Thea Horaud

Diversity of Structures Carrying the High-Level Gentamicin Resistance Gene (aac6-aph2) in Enterococcus faecalis Strains Isolated in France
Antimicrob. Agents Chemother. 1998 42: 2889-2892. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Wanzhi Huang, Joseph Petrosino, and Timothy Palzkill

Display of Functional -Lactamase Inhibitory Protein on the Surface of M13 Bacteriophage
Antimicrob. Agents Chemother. 1998 42: 2893-2897. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

James M. Battisti, Laura S. Smitherman, D. Scott Samuels, and Michael F. Minnick

Mutations in Bartonella bacilliformis gyrB Confer Resistance to Coumermycin A₁
Antimicrob. Agents Chemother. 1998 42: 2906-2913. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Glenn A. Pankuch, Shane A. Jueneman, Todd A. Davies, Michael R. Jacobs, and Peter C. Appelbaum

In Vitro Selection of Resistance to Four -Lactams and Azithromycin in Streptococcus pneumoniae
Antimicrob. Agents Chemother. 1998 42: 2914-2918. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Catherine A. Ison, Patricia J. Woodford, Helen Madders, and Elizabeth Claydon

Drift in Susceptibility of Neisseria gonorrhoeae to Ciprofloxacin and Emergence of Therapeutic Failure
Antimicrob. Agents Chemother. 1998 42: 2919-2922. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jose L. Lopez-Ribot, Robert K. McAtee, Linda N. Lee, William R. Kirkpatrick, Theodore C. White, Dominique Sanglard, and Thomas F. Patterson

Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis
Antimicrob. Agents Chemother. 1998 42: 2932-2937. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

John R. Graybill, Eleanor Montalbo, William R. Kirkpatrick, Michael F. Luther, Sanjay G. Revankar, and Thomas F. Patterson

Fluconazole versus Candida albicans: A Complex Relationship
Antimicrob. Agents Chemother. 1998 42: 2938-2942. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Naoyoshi Suzuki, Chang-Kwon Lee, Takuya Nihira, and Yasuhiro Yamada

Purification and Characterization of Virginiamycin M₁ Reductase from Streptomyces virginiae
Antimicrob. Agents Chemother. 1998 42: 2985-2988. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Federico G. Nicola, Linda K. McDougal, James W. Biddle, and Fred C. Tenover

Characterization of Erythromycin-Resistant Isolates of Staphylococcus aureus Recovered in the United States from 1958 through 1969
Antimicrob. Agents Chemother. 1998 42: 3024-3027. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mayumi Tanaka, Yoshikuni Onodera, Yoko Uchida, and Kenichi Sato

Quinolone Resistance Mutations in the GrlB Protein of Staphylococcus aureus
Antimicrob. Agents Chemother. 1998 42: 3044-3046. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Selwyn J. Hurwitz, Bud C. Tennant, Brent E. Korba, John L. Gerin, and Raymond F. Schinazi

Pharmacodynamics of ()--2',3'-Dideoxy-3'-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans
Antimicrob. Agents Chemother. 1998 42: 2804-2809. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Erik A. Gustafson, Antoinette C. Chillemi, David R. Sage, and Joyce D. Fingeroth

The Epstein-Barr Virus Thymidine Kinase Does Not Phosphorylate Ganciclovir or Acyclovir and Demonstrates a Narrow Substrate Specificity Compared to the Herpes Simplex Virus Type 1 Thymidine Kinase
Antimicrob. Agents Chemother. 1998 42: 2923-2931. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Stephen L. Sacks, Stephen D. Shafran, Francisco Diaz-Mitoma, Sylvie Trottier, R. Gary Sibbald, April Hughes, Sharon Safrin, Jeff Rudy, Brian McGuire, and Howard S. Jaffe

A Multicenter Phase I/II Dose Escalation Study of Single-Dose Cidofovir Gel for Treatment of Recurrent Genital Herpes
Antimicrob. Agents Chemother. 1998 42: 2996-2999. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Gilda Tachedjian, Martyn French, and John Mills

Coresistance to Zidovudine and Foscarnet Is Associated with Multiple Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase
Antimicrob. Agents Chemother. 1998 42: 3038-3043. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

Knut Ohlsen, Wilma Ziebuhr, Klaus-Peter Koller, Wolfgang Hell, Thomas A. Wichelhaus, and Jörg Hacker

Effects of Subinhibitory Concentrations of Antibiotics on Alpha-Toxin (hla) Gene Expression of Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Isolates
Antimicrob. Agents Chemother. 1998 42: 2817-2823. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Seiichi Kobayashi, Tsutomu Kawata, Akifumi Kimura, Kaname Miyamoto, Koichi Katayama, Isao Yamatsu, Daniel P. Rossignol, William J. Christ, and Yoshito Kishi

Suppression of Murine Endotoxin Response by E5531, a Novel Synthetic Lipid A Antagonist
Antimicrob. Agents Chemother. 1998 42: 2824-2829. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tetsuya Matsumoto, Kazuhiro Tateda, Shuichi Miyazaki, Nobuhiko Furuya, Akira Ohno, Yoshikazu Ishii, Yoichi Hirakata, and Keizo Yamaguchi

Effect of Interleukin-10 on Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice
Antimicrob. Agents Chemother. 1998 42: 2853-2857. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Azzam Saleh Mghir, Anne Claude Crémieux, Rémy Bleton, Farid Ismael, Michel Manteau, Sophie Dautrey, Laurent Massias, Louis Garry, Nicole Sales, Bernard Mazière, and Claude Carbon

Efficacy of Teicoplanin and Autoradiographic Diffusion Pattern of [¹⁴C]Teicoplanin in Experimental Staphylococcus aureus Infection of Joint Prostheses
Antimicrob. Agents Chemother. 1998 42: 2830-2835. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ronald Kaminsky and Reto Brun

In Vitro and In Vivo Activities of Trybizine Hydrochloride against Various Pathogenic Trypanosome Species
Antimicrob. Agents Chemother. 1998 42: 2858-2862. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Byron L. Blagburn, Kathryn L. Drain, Tracey M. Land, Rachel G. Kinard, P. Hutton Moore, David S. Lindsay, Donald A. Patrick, David W. Boykin, and Richard R. Tidwell

Comparative Efficacy Evaluation of Dicationic Carbazole Compounds, Nitazoxanide, and Paromomycin against Cryptosporidium parvum Infections in a Neonatal Mouse Model
Antimicrob. Agents Chemother. 1998 42: 2877-2882. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Vidmantas Petraitis, Ruta Petraitiene, Andreas H. Groll, Aaron Bell, Diana P. Callender, Tin Sein, Robert L. Schaufele, Carl L. McMillian, John Bacher, and Thomas J. Walsh

Antifungal Efficacy, Safety, and Single-Dose Pharmacokinetics of LY303366, a Novel Echinocandin B, in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits
Antimicrob. Agents Chemother. 1998 42: 2898-2905. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Maria Jiménez-Valera, Concepción Gonzalez-Torres, Encarnación Moreno, and Alfonso Ruiz-Bravo

Comparison of Ceftriaxone, Amikacin, and Ciprofloxacin in Treatment of Experimental Yersinia enterocolitica O9 Infection in Mice
Antimicrob. Agents Chemother. 1998 42: 3009-3011. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jason V. Brooks and Ian M. Orme

Evaluation of Once-Weekly Therapy for Tuberculosis Using Isoniazid plus Rifamycins in the Mouse Aerosol Infection Model
Antimicrob. Agents Chemother. 1998 42: 3047-3048. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Francis Mégraud, Alessandra Occhialini, and Jean François Rossignol

Nitazoxanide, a Potential Drug for Eradication of Helicobacter pylori with No Cross-Resistance to Metronidazole
Antimicrob. Agents Chemother. 1998 42: 2836-2840. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

E. Herreros, C. M. Martinez, M. J. Almela, M. S. Marriott, F. Gomez De Las Heras, and D. Gargallo-Viola

Sordarins: In Vitro Activities of New Antifungal Derivatives against Pathogenic Yeasts, Pneumocystis carinii, and Filamentous Fungi
Antimicrob. Agents Chemother. 1998 42: 2863-2869. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Makoto Matsumoto, Hisashi Tamaoka, Hiroshi Ishikawa, and Mikio Kikuchi

In Vitro and In Vivo Antibacterial Activities of OPC-20011, a Novel Parenteral Broad-Spectrum 2-Oxaisocephem Antibiotic
Antimicrob. Agents Chemother. 1998 42: 2943-2949. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laura J. V. Piddock, M. Johnson, V. Ricci, and S. L. Hill

Activities of New Fluoroquinolones against Fluoroquinolone-Resistant Pathogens of the Lower Respiratory Tract
Antimicrob. Agents Chemother. 1998 42: 2956-2960. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Robin K. Pettit, George R. Pettit, and Kevin C. Hazen

Specific Activities of Dolastatin 10 and Peptide Derivatives against Cryptococcus neoformans
Antimicrob. Agents Chemother. 1998 42: 2961-2965. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

R. Piccolomini, G. Catamo, and G. Di Bonaventura

Bacteriostatic and Bactericidal In Vitro Activities of Clarithromycin and Erythromycin against Periodontopathic Actinobacillus actinomycetemcomitans
Antimicrob. Agents Chemother. 1998 42: 3000-3001. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael M. Tunney, Gordon Ramage, Sheila Patrick, James R. Nixon, Philip G. Murphy, and Sean P. Gorman

Antimicrobial Susceptibility of Bacteria Isolated from Orthopedic Implants following Revision Hip Surgery
Antimicrob. Agents Chemother. 1998 42: 3002-3005. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lionel Horgen, Arnaud Jerome, and Nalin Rastogi

Pulsed-Exposure and Postantibiotic Leukocyte Enhancement Effects of Amikacin, Clarithromycin, Clofazimine, and Rifampin against Intracellular Mycobacterium avium
Antimicrob. Agents Chemother. 1998 42: 3006-3008. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

C. Rimaroli and T. Bruzzese

In Vitro Activity of a New Polyene, SPA-S-843, against Yeasts
Antimicrob. Agents Chemother. 1998 42: 3012-3013. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Elias K. Manavathu, Jessica L. Cutright, and Pranatharthi H. Chandrasekar

Organism-Dependent Fungicidal Activities of Azoles
Antimicrob. Agents Chemother. 1998 42: 3018-3021. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

María T. Andrés, Whasun O. Chung, Marilyn C. Roberts, and José F. Fierro

Antimicrobial Susceptibilities of Porphyromonas gingivalis, Prevotella intermedia, and Prevotella nigrescens spp. Isolated in Spain
Antimicrob. Agents Chemother. 1998 42: 3022-3023. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Glenn A. Pankuch, Michael R. Jacobs, and Peter C. Appelbaum

Postantibiotic Effect and Postantibiotic Sub-MIC Effect of Quinupristin-Dalfopristin against Gram-Positive and -Negative Organisms
Antimicrob. Agents Chemother. 1998 42: 3028-3031. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Glenn A. Pankuch, Dianne B. Hoellman, Gengrong Lin, Saralee Bajaksouzian, Michael R. Jacobs, and Peter C. Appelbaum

Activity of HMR 3647 Compared to Those of Five Agents against Haemophilus influenzae and Moraxella catarrhalis by MIC Determination and Time-Kill Assay
Antimicrob. Agents Chemother. 1998 42: 3032-3034. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Delia Deidda, Giorgio Lampis, Rossella Fioravanti, Mariangela Biava, Giulio Cesare Porretta, Stefania Zanetti, and Raffaello Pompei

Bactericidal Activities of the Pyrrole Derivative BM212 against Multidrug-Resistant and Intramacrophagic Mycobacterium tuberculosis Strains
Antimicrob. Agents Chemother. 1998 42: 3035-3037. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

P. Christian Lück, Jürgen W. Schmitt, Arne Hengerer, and Jürgen H. Helbig

Subinhibitory Concentrations of Antimicrobial Agents Reduce the Uptake of Legionella pneumophila into Acanthamoeba castellanii and U937 Cells by Altering the Expression of Virulence-Associated Antigens
Antimicrob. Agents Chemother. 1998 42: 2870-2876. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mathirut Mungthin, Patrick G. Bray, Robert G. Ridley, and Stephen A. Ward

Central Role of Hemoglobin Degradation in Mechanisms of Action of 4-Aminoquinolines, Quinoline Methanols, and Phenanthrene Methanols
Antimicrob. Agents Chemother. 1998 42: 2973-2977. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yuzhi Dong, Chen Xu, Xilin Zhao, John Domagala, and Karl Drlica

Fluoroquinolone Action against Mycobacteria: Effects of C-8 Substituents on Growth, Survival, and Resistance
Antimicrob. Agents Chemother. 1998 42: 2978-2984. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

C. Jaccard, N. Troillet, S. Harbarth, G. Zanetti, D. Aymon, R. Schneider, R. Chiolero, B. Ricou, J. Romand, O. Huber, P. Ambrosetti, G. Praz, D. Lew, J. Bille, M. P. Glauser, and A. Cometta

Prospective Randomized Comparison of Imipenem-Cilastatin and Piperacillin-Tazobactam in Nosocomial Pneumonia or Peritonitis
Antimicrob. Agents Chemother. 1998 42: 2966-2972. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Henrik Caspar Wegener

Historical Yearly Usage of Glycopeptides for Animals and Humans: The American-European Paradox Revisited
Antimicrob. Agents Chemother. 1998 42: 3049. [Full Text] [PDF] [Reprints and Permissions]  

Laura M. McMurry and Stuart B. Levy

Revised Sequence of OtrB (Tet347) Tetracycline Efflux Protein from Streptomyces rimosus
Antimicrob. Agents Chemother. 1998 42: 3050. [Full Text] [PDF] [Reprints and Permissions]  

Yiu-Wai Chu, Elizabeth T. S. Houang, and Augustine F. B. Cheng

Novel Combination of Mutations in the DNA Gyrase and Topoisomerase IV Genes in Laboratory-Grown Fluoroquinolone-Resistant Shigella flexneri Mutants
Antimicrob. Agents Chemother. 1998 42: 3051-3052. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.