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Mechanisms of Resistance:

Simona Bratu, David Landman, Don Antonio Martin, Claudiu Georgescu, and John Quale

Correlation of Antimicrobial Resistance with β-Lactamases, the OmpA-Like Porin, and Efflux Pumps in Clinical Isolates of Acinetobacter baumannii Endemic to New York City
Antimicrob. Agents Chemother. 2008 52: 2999-3005. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ulysses W. Sallum and Thomas T. Chen

Inducible Resistance of Fish Bacterial Pathogens to the Antimicrobial Peptide Cecropin B
Antimicrob. Agents Chemother. 2008 52: 3006-3012. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

H. Sahly, S. Navon-Venezia, L. Roesler, A. Hay, Y. Carmeli, R. Podschun, C. Hennequin, C. Forestier, and I. Ofek

Extended-Spectrum β-Lactamase Production Is Associated with an Increase in Cell Invasion and Expression of Fimbrial Adhesins in Klebsiella pneumoniae
Antimicrob. Agents Chemother. 2008 52: 3029-3034. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Feng Long, Corinne Rouquette-Loughlin, William M. Shafer, and Edward W. Yu

Functional Cloning and Characterization of the Multidrug Efflux Pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli
Antimicrob. Agents Chemother. 2008 52: 3052-3060. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Marie Desnos-Ollivier, Stéphane Bretagne, Dorothée Raoux, Damien Hoinard, Françoise Dromer, and Eric Dannaoui

Mutations in the fks1 Gene in Candida albicans, C. tropicalis, and C. krusei Correlate with Elevated Caspofungin MICs Uncovered in AM3 Medium Using the Method of the European Committee on Antibiotic Susceptibility Testing
Antimicrob. Agents Chemother. 2008 52: 3092-3098. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hongyang Li, Mark A. Toleman, Peter M. Bennett, Ronald N. Jones, and Timothy R. Walsh

Complete Sequence of p07-406, a 24,179-Base-Pair Plasmid Harboring the bla_VIM-7 Metallo-β-Lactamase Gene in a Pseudomonas aeruginosa Isolate from the United States
Antimicrob. Agents Chemother. 2008 52: 3099-3105. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Olga Danilchanka, Mikhail Pavlenok, and Michael Niederweis

Role of Porins for Uptake of Antibiotics by Mycobacterium smegmatis
Antimicrob. Agents Chemother. 2008 52: 3127-3134. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Frédérique Vernel-Pauillac, Sobhan Nandi, Robert A. Nicholas, and Cyrille Goarant

Genotyping as a Tool for Antibiotic Resistance Surveillance of Neisseria gonorrhoeae in New Caledonia: Evidence of a Novel Genotype Associated with Reduced Penicillin Susceptibility
Antimicrob. Agents Chemother. 2008 52: 3293-3300. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Manzour Hernando Hazbón, Alifiya S. Motiwala, Magali Cavatore, Michael Brimacombe, Thomas S. Whittam, and David Alland

Convergent Evolutionary Analysis Identifies Significant Mutations in Drug Resistance Targets of Mycobacterium tuberculosis
Antimicrob. Agents Chemother. 2008 52: 3369-3376. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Joanna E. Mroczkowska and Miriam Barlow

Recombination and Selection Can Remove bla_TEM Alleles from Bacterial Populations
Antimicrob. Agents Chemother. 2008 52: 3408-3410. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Louis B. Rice, Lenore L. Carias, Rebecca A. Hutton, Susan D. Rudin, Andrea Endimiani, and Robert A. Bonomo

The KQ Element, a Complex Genetic Region Conferring Transferable Resistance to Carbapenems, Aminoglycosides, and Fluoroquinolones in Klebsiella pneumoniae
Antimicrob. Agents Chemother. 2008 52: 3427-3429. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Alexey Ruzin, Frederick W. Immermann, and Patricia A. Bradford

Real-Time PCR and Statistical Analyses of acrAB and ramA Expression in Clinical Isolates of Klebsiella pneumoniae
Antimicrob. Agents Chemother. 2008 52: 3430-3432. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Mark Holodniy, Scott R. Penzak, Timothy M. Straight, Richard T. Davey, Kelvin K. Lee, Matthew Bidwell Goetz, Dennis W. Raisch, Francesca Cunningham, Emil T. Lin, Noemi Olivo, and Lawrence R. Deyton

Pharmacokinetics and Tolerability of Oseltamivir Combined with Probenecid
Antimicrob. Agents Chemother. 2008 52: 3013-3021. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Warren E. Rose, Steven N. Leonard, and Michael J. Rybak

Evaluation of Daptomycin Pharmacodynamics and Resistance at Various Dosage Regimens against Staphylococcus aureus Isolates with Reduced Susceptibilities to Daptomycin in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations
Antimicrob. Agents Chemother. 2008 52: 3061-3067. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Sandrine Marchand, Denis Frasca, Claire Dahyot-Fizelier, Céline Breheret, Olivier Mimoz, and William Couet

Lung Microdialysis Study of Levofloxacin in Rats following Intravenous Infusion at Steady State
Antimicrob. Agents Chemother. 2008 52: 3074-3077. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Johannes Nagelschmitz, Barbara Voith, Georg Wensing, Axel Roemer, Burkhard Fugmann, Richard K. Haynes, Barbara M. Kotecka, Karl H. Rieckmann, and Michael D. Edstein

First Assessment in Humans of the Safety, Tolerability, Pharmacokinetics, and Ex Vivo Pharmacodynamic Antimalarial Activity of the New Artemisinin Derivative Artemisone
Antimicrob. Agents Chemother. 2008 52: 3085-3091. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

John W. Baddley, Mukesh Patel, Sujata M. Bhavnani, Stephen A. Moser, and David R. Andes

Association of Fluconazole Pharmacodynamics with Mortality in Patients with Candidemia
Antimicrob. Agents Chemother. 2008 52: 3022-3028. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Fe Eleanor F. Pardillo, Jasmin Burgos, Tranquilino T. Fajardo, Eduardo Dela Cruz, Rodolfo M. Abalos, Rose Maria D. Paredes, Cora Evelyn S. Andaya, and Robert H. Gelber

Powerful Bactericidal Activity of Moxifloxacin in Human Leprosy
Antimicrob. Agents Chemother. 2008 52: 3113-3117. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Annie-Claude Labbé, Louise Poirier, Duncan MacCannell, Thomas Louie, Michel Savoie, Claire Béliveau, Michel Laverdière, and Jacques Pépin

Clostridium difficile Infections in a Canadian Tertiary Care Hospital before and during a Regional Epidemic Associated with the BI/NAP1/027 Strain
Antimicrob. Agents Chemother. 2008 52: 3180-3187. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael Y. Lin, Robert A. Weinstein, and Bala Hota

Delay of Active Antimicrobial Therapy and Mortality among Patients with Bacteremia: Impact of Severe Neutropenia
Antimicrob. Agents Chemother. 2008 52: 3188-3194. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mario Tumbarello, Michela Sali, Enrico Maria Trecarichi, Fiammetta Leone, Marianna Rossi, Barbara Fiori, Gennaro De Pascale, Tiziana D'Inzeo, Maurizio Sanguinetti, Giovanni Fadda, Roberto Cauda, and Teresa Spanu

Bloodstream Infections Caused by Extended-Spectrum-β-Lactamase- Producing Escherichia coli: Risk Factors for Inadequate Initial Antimicrobial Therapy
Antimicrob. Agents Chemother. 2008 52: 3244-3252. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Brian L. Robbins, Edmund V. Capparelli, Ellen G. Chadwick, Ram Yogev, Leslie Serchuck, Carol Worrell, Mary Elizabeth Smith, Carmelita Alvero, Terence Fenton, Barbara Heckman, Stephen I. Pelton, Grace Aldrovandi, William Borkowsky, John Rodman, Peter L. Havens for the PACTG 1038 Team

Pharmacokinetics of High-Dose Lopinavir-Ritonavir with and without Saquinavir or Nonnucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus-Infected Pediatric and Adolescent Patients Previously Treated with Protease Inhibitors
Antimicrob. Agents Chemother. 2008 52: 3276-3283. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

T. P. Lodise, J. Graves, A. Evans, E. Graffunder, M. Helmecke, B. M. Lomaestro, and K. Stellrecht

Relationship between Vancomycin MIC and Failure among Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia Treated with Vancomycin
Antimicrob. Agents Chemother. 2008 52: 3315-3320. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Carlo McCalla, Davida S. Smyth, D. Ashley Robinson, Judith Steenbergen, Steven A. Luperchio, Pamela A. Moise, Vance G. Fowler, Jr., and George Sakoulas

Microbiological and Genotypic Analysis of Methicillin-Resistant Staphylococcus aureus Bacteremia
Antimicrob. Agents Chemother. 2008 52: 3441-3443. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Robert DiCenzo, Derick R. Peterson, Kim Cruttenden, Peter Mariuz, Naser L. Rezk, Jill Hochreiter, Harris Gelbard, and Giovanni Schifitto

Effects of Minocycline and Valproic Acid Coadministration on Atazanavir Plasma Concentrations in Human Immunodeficiency Virus-Infected Adults Receiving Atazanavir-Ritonavir
Antimicrob. Agents Chemother. 2008 52: 3035-3039. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Séverine Margeridon, Sandra Carrouée-Durantel, Isabelle Chemin, Luc Barraud, Fabien Zoulim, Christian Trépo, and Alan Kay

Rolling Circle Amplification, a Powerful Tool for Genetic and Functional Studies of Complete Hepatitis B Virus Genomes from Low-Level Infections and for Directly Probing Covalently Closed Circular DNA
Antimicrob. Agents Chemother. 2008 52: 3068-3073. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Debora Pinna, Pasqua Oreste, Tiziana Coradin, Anna Kajaste-Rudnitski, Silvia Ghezzi, Giorgio Zoppetti, Antonella Rotola, Rafaela Argnani, Guido Poli, Roberto Manservigi, and Elisa Vicenzi

Inhibition of Herpes Simplex Virus Types 1 and 2 In Vitro Infection by Sulfated Derivatives of Escherichia coli K5 Polysaccharide
Antimicrob. Agents Chemother. 2008 52: 3078-3084. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Koen K. A. Van Rompay, Lucie Durand-Gasselin, Laurie L. Brignolo, Adrian S. Ray, Kristina Abel, Tomas Cihlar, Abigail Spinner, Christopher Jerome, Joseph Moore, Brian P. Kearney, Marta L. Marthas, Hans Reiser, and Norbert Bischofberger

Chronic Administration of Tenofovir to Rhesus Macaques from Infancy through Adulthood and Pregnancy: Summary of Pharmacokinetics and Biological and Virological Effects
Antimicrob. Agents Chemother. 2008 52: 3144-3160. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Deidra Shuck-Lee, Fei Fei Chen, Ryan Willard, Sharmila Raman, Roger Ptak, Marie-Louise Hammarskjold, and David Rekosh

Heterocyclic Compounds That Inhibit Rev-RRE Function and Human Immunodeficiency Virus Type 1 Replication
Antimicrob. Agents Chemother. 2008 52: 3169-3179. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anne-Genevieve Marcelin, Bernard Masquelier, Diane Descamps, Jacques Izopet, Charlotte Charpentier, Chakib Alloui, Magali Bouvier-Alias, Anne Signori-Schmuck, Brigitte Montes, Marie-Laure Chaix, Corinne Amiel, Georges Dos Santos, Annick Ruffault, Francis Barin, Gilles Peytavin, Marc Lavignon, Philippe Flandre, and Vincent Calvez

Tipranavir-Ritonavir Genotypic Resistance Score in Protease Inhibitor-Experienced Patients
Antimicrob. Agents Chemother. 2008 52: 3237-3243. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Larissa A. Wenning, Evan J. Friedman, James T. Kost, Sheila A. Breidinger, Jon E. Stek, Kenneth C. Lasseter, Keith M. Gottesdiener, Joshua Chen, Hedy Teppler, John A. Wagner, Julie A. Stone, and Marian Iwamoto

Lack of a Significant Drug Interaction between Raltegravir and Tenofovir
Antimicrob. Agents Chemother. 2008 52: 3253-3258. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Joanna E. Mathy, Sue Ma, Teresa Compton, and Kai Lin

Combinations of Cyclophilin Inhibitor NIM811 with Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance
Antimicrob. Agents Chemother. 2008 52: 3267-3275. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tiffany G. Sheu, Varough M. Deyde, Margaret Okomo-Adhiambo, Rebecca J. Garten, Xiyan Xu, Rick A. Bright, Eboneé N. Butler, Teresa R. Wallis, Alexander I. Klimov, and Larisa V. Gubareva

Surveillance for Neuraminidase Inhibitor Resistance among Human Influenza A and B Viruses Circulating Worldwide from 2004 to 2008
Antimicrob. Agents Chemother. 2008 52: 3284-3292. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anita Y. M. Howe, Huiming Cheng, Stephen Johann, Stanley Mullen, Srinivas K. Chunduru, Dorothy C. Young, Joel Bard, Rajiv Chopra, Girija Krishnamurthy, Tarek Mansour, and John O'Connell

Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796
Antimicrob. Agents Chemother. 2008 52: 3327-3338. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jacob A. Zahm, Sibes Bera, Krishan K. Pandey, Ajaykumar Vora, Kara Stillmock, Daria Hazuda, and Duane P. Grandgenett

Mechanisms of Human Immunodeficiency Virus Type 1 Concerted Integration Related to Strand Transfer Inhibition and Drug Resistance
Antimicrob. Agents Chemother. 2008 52: 3358-3368. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hubert Schulbin, Hagen Bode, Hartmut Stocker, Wolfgang Schmidt, Thomas Zippel, Christoph Loddenkemper, Elisabeth Engelmann, Hans-Jörg Epple, Keikawus Arastéh, Martin Zeitz and Reiner Ullrich for the Kompetenznetz HIV/AIDS Germany

Cytokine Expression in the Colonic Mucosa of Human Immunodeficiency Virus-Infected Individuals before and during 9 Months of Antiretroviral Therapy
Antimicrob. Agents Chemother. 2008 52: 3377-3384. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Niklaus H. Mueller, Nagarajan Pattabiraman, Camilo Ansarah-Sobrinho, Prasanth Viswanathan, Theodore C. Pierson, and R. Padmanabhan

Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput Screen
Antimicrob. Agents Chemother. 2008 52: 3385-3393. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jan Paeshuyse, Inge Vliegen, Lotte Coelmont, Pieter Leyssen, Oriana Tabarrini, Piet Herdewijn, Harald Mittendorfer, Johnny Easmon, Violetta Cecchetti, Ralf Bartenschlager, Gerhard Puerstinger, and Johan Neyts

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors
Antimicrob. Agents Chemother. 2008 52: 3433-3437. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Guangshun Wang, Karen M. Watson, and Robert W. Buckheit, Jr.

Anti-Human Immunodeficiency Virus Type 1 Activities of Antimicrobial Peptides Derived from Human and Bovine Cathelicidins
Antimicrob. Agents Chemother. 2008 52: 3438-3440. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

Ann Lismond, Paul M. Tulkens, Marie-Paule Mingeot-Leclercq, Patrice Courvalin, and Françoise Van Bambeke

Cooperation between Prokaryotic (Lde) and Eukaryotic (MRP) Efflux Transporters in J774 Macrophages Infected with Listeria monocytogenes: Studies with Ciprofloxacin and Moxifloxacin
Antimicrob. Agents Chemother. 2008 52: 3040-3046. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Christopher R. Bethel, Anne M. Distler, Mark W. Ruszczycky, Marianne P. Carey, Paul R. Carey, Andrea M. Hujer, Magda Taracila, Marion S. Helfand, Jodi M. Thomson, Matthew Kalp, Vernon E. Anderson, David A. Leonard, Kristine M. Hujer, Takao Abe, Aranapakam M. Venkatesan, Tarek S. Mansour, and Robert A. Bonomo

Inhibition of OXA-1 β-Lactamase by Penems
Antimicrob. Agents Chemother. 2008 52: 3135-3143. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

George P. Tegos, Kayo Masago, Fatima Aziz, Andrew Higginbotham, Frank R. Stermitz, and Michael R. Hamblin

Inhibitors of Bacterial Multidrug Efflux Pumps Potentiate Antimicrobial Photoinactivation
Antimicrob. Agents Chemother. 2008 52: 3202-3209. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Eithne Cunningham, Marcin Drag, Pawel Kafarski, and Angus Bell

Chemical Target Validation Studies of Aminopeptidase in Malaria Parasites Using -Aminoalkylphosphonate and Phosphonopeptide Inhibitors
Antimicrob. Agents Chemother. 2008 52: 3221-3228. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Martti Vaara, John Fox, Günther Loidl, Osmo Siikanen, Juha Apajalahti, Frank Hansen, Niels Frimodt-Møller, Junya Nagai, Mikihisa Takano, and Timo Vaara

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents
Antimicrob. Agents Chemother. 2008 52: 3229-3236. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael T. Black, Thérèse Stachyra, Denis Platel, Anne-Marie Girard, Monique Claudon, Jean-Michel Bruneau, and Christine Miossec

Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases
Antimicrob. Agents Chemother. 2008 52: 3339-3349. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lili Rosana Mesak, Vivian Miao, and Julian Davies

Effects of Subinhibitory Concentrations of Antibiotics on SOS and DNA Repair Gene Expression in Staphylococcus aureus
Antimicrob. Agents Chemother. 2008 52: 3394-3397. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Chemistry; Biosynthesis:

Stephanie J. Wallace, Jian Li, Craig. R. Rayner, Kingsley Coulthard, and Roger L. Nation

Stability of Colistin Methanesulfonate in Pharmaceutical Products and Solutions for Administration to Patients
Antimicrob. Agents Chemother. 2008 52: 3047-3051. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Autumn S. Downey, Curtis R. Chong, Thaddeus K. Graczyk, and David J. Sullivan

Efficacy of Pyrvinium Pamoate against Cryptosporidium parvum Infection In Vitro and in a Neonatal Mouse Model
Antimicrob. Agents Chemother. 2008 52: 3106-3112. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Alexandra Vallon-Eberhard, Arik Makovitzki, Anne Beauvais, Jean-Paul Latgé, Steffen Jung, and Yechiel Shai

Efficient Clearance of Aspergillus fumigatus in Murine Lungs by an Ultrashort Antimicrobial Lipopeptide, Palmitoyl-Lys-Ala-DAla-Lys
Antimicrob. Agents Chemother. 2008 52: 3118-3126. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rahul Kumar Verma, Jatinder Kaur, Kaushlendra Kumar, Awadh Bihari Yadav, and Amit Misra

Intracellular Time Course, Pharmacokinetics, and Biodistribution of Isoniazid and Rifabutin following Pulmonary Delivery of Inhalable Microparticles to Mice
Antimicrob. Agents Chemother. 2008 52: 3195-3201. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Solène Grayo, Marie-Catherine Lott-Desroches, Olivier Dussurget, Renaud Respaud, Arnaud Fontanet, Olivier Join-Lambert, Eric Singlas, and Alban Le Monnier

Rapid Eradication of Listeria monocytogenes by Moxifloxacin in a Murine Model of Central Nervous System Listeriosis
Antimicrob. Agents Chemother. 2008 52: 3210-3215. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Cristiane França da Silva, Marcos Meuser Batista, Denise da Gama Jaen Batista, Elen Mello de Souza, Patrícia Bernardino da Silva, Gabriel Melo de Oliveira, Andrea Souza Meuser, Abdur-Rafay Shareef, David W. Boykin, and Maria de Nazaré C. Soeiro

In Vitro and In Vivo Studies of the Trypanocidal Activity of a Diarylthiophene Diamidine against Trypanosoma cruzi
Antimicrob. Agents Chemother. 2008 52: 3307-3314. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Esther Vicente, Raquel Villar, Asunción Burguete, Beatriz Solano, Silvia Pérez-Silanes, Ignacio Aldana, Joseph A. Maddry, Anne J. Lenaerts, Scott G. Franzblau, Sang-hyun Cho, Antonio Monge, and Robert C. Goldman

Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis
Antimicrob. Agents Chemother. 2008 52: 3321-3326. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

H. S. Heine, J. Bassett, L. Miller, A. Bassett, B. E. Ivins, D. Lehoux, F. F. Arhin, T. R. Parr, Jr., and G. Moeck

Efficacy of Oritavancin in a Murine Model of Bacillus anthracis Spore Inhalation Anthrax
Antimicrob. Agents Chemother. 2008 52: 3350-3357. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Martin Spicher, Carole Roethlisberger, Catharina Lany, Britta Stadelmann, Jennifer Keiser, Luis M. Ortega-Mora, Bruno Gottstein, and Andrew Hemphill

In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives
Antimicrob. Agents Chemother. 2008 52: 3447-3450. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Won-Hwan Park, Sung-Jae Lee, and Hyung-In Moon

Antimalarial Activity of a New Stilbene Glycoside from Parthenocissus tricuspidata in Mice
Antimicrob. Agents Chemother. 2008 52: 3451-3453. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Fumie Abe, Jun Ueyama, Noriyo Kawasumi, Masayuki Nadai, Tamon Hayashi, Miki Kato, Masafumi Ohnishi, Hiroko Saito, Naoshi Takeyama, and Takaaki Hasegawa

Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats
Antimicrob. Agents Chemother. 2008 52: 3454-3456. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael J. Pultz, Michelle M. Nerandzic, Usha Stiefel, and Curtis J. Donskey

Emergence and Acquisition of Fluoroquinolone-Resistant Gram-Negative Bacilli in the Intestinal Tracts of Mice Treated with Fluoroquinolone Antimicrobial Agents
Antimicrob. Agents Chemother. 2008 52: 3457-3460. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Chia-Ying Liu, Yu-Tsung Huang, Chun-Hsing Liao, Li-Ching Yen, Hsiu-Ying Lin, and Po-Ren Hsueh

Increasing Trends in Antimicrobial Resistance among Clinically Important Anaerobes and Bacteroides fragilis Isolates Causing Nosocomial Infections: Emerging Resistance to Carbapenems
Antimicrob. Agents Chemother. 2008 52: 3161-3168. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Heather Amrine-Madsen, Johan Van Eldere, Robertino M. Mera, Linda A. Miller, James A. Poupard, Elizabeth S. Thomas, Wendy S. Halsey, Julie A. Becker, and F. Patrick O'Hara

Temporal and Spatial Distribution of Clonal Complexes of Streptococcus pneumoniae Isolates Resistant to Multiple Classes of Antibiotics in Belgium, 1997 to 2004
Antimicrob. Agents Chemother. 2008 52: 3216-3220. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

C. J. Seneviratne, L. J. Jin, Y. H. Samaranayake, and L. P. Samaranayake

Cell Density and Cell Aging as Factors Modulating Antifungal Resistance of Candida albicans Biofilms
Antimicrob. Agents Chemother. 2008 52: 3259-3266. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yigong Ge, Donald Biek, George H. Talbot, and Daniel F. Sahm

In Vitro Profiling of Ceftaroline against a Collection of Recent Bacterial Clinical Isolates from across the United States
Antimicrob. Agents Chemother. 2008 52: 3398-3407. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jeniel E. Nett, Kristie M. Guite, Alex Ringeisen, Kathleen A. Holoyda, and David R. Andes

Reduced Biocide Susceptibility in Candida albicans Biofilms
Antimicrob. Agents Chemother. 2008 52: 3411-3413. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Romanico B. G. Arrighi, Charles Ebikeme, Yang Jiang, Lisa Ranford-Cartwright, Michael P. Barrett, Ülo Langel, and Ingrid Faye

Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei
Antimicrob. Agents Chemother. 2008 52: 3414-3417. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Karen M. Amsler, Todd A. Davies, Wenchi Shang, Michael R. Jacobs, and Karen Bush

In Vitro Activity of Ceftobiprole against Pathogens from Two Phase 3 Clinical Trials of Complicated Skin and Skin Structure Infections
Antimicrob. Agents Chemother. 2008 52: 3418-3423. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Scott E. Gygax, John-Paul Vermitsky, Sean G. Chadwick, Matthew J. Self, Jessica A. Zimmerman, Eli Mordechai, Martin E. Adelson, and Jason P. Trama

Antifungal Resistance of Candida glabrata Vaginal Isolates and Development of a Quantitative Reverse Transcription-PCR-Based Azole Susceptibility Assay
Antimicrob. Agents Chemother. 2008 52: 3424-3426. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jesús Guinea, Sandra Recio, Teresa Peláez, Marta Torres-Narbona, and Emilio Bouza

Clinical Isolates of Aspergillus Species Remain Fully Susceptible to Voriconazole in the Post-Voriconazole Era
Antimicrob. Agents Chemother. 2008 52: 3444-3446. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

Maria Simitsopoulou, Emmanuel Roilides, Fotini Paliogianni, Christodoulos Likartsis, John Ioannidis, Kalliopi Kanellou, and Thomas J. Walsh

Immunomodulatory Effects of Voriconazole on Monocytes Challenged with Aspergillus fumigatus: Differential Role of Toll-Like Receptors
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